Invited Speaker
Dr. Anca Mazare
Department of Materials Science – WW4-LKO,Friedrich-Alexander University of Erlangen Nurnberg, Germany
Speech Title: TiO2 Nanostructures by Electrochemical Anodization – Morphology and Biomedical Applications
Abstract: Nanostructuring of titanium is a well-established surface modification approach, resulting in ideal implant biomaterials, as it improves biocompatibility and corrosion resistance. Of the various surface modification techniques, electrochemical anodization is one of the most widely used, leading to self-organized TiO2 nanostructures (nanotubes, nanopores, mesoporous, etc.) [1-3]. The nanotopography of the nanotubular surface clearly influences their use e.g., in osseointegration, antibacterial activity, drug delivery, mitigation of the inflammatory response, etc. [2-6]. Cells react to such nanoscale dimensions and can be synergistically influenced by the nanostructures morphology (e.g. nanotube diameter) and/or by addition of growth factors [4-6]. We will further discuss the key parameters resulting into different nanotubular morphologies, and their effect on the resulting top surface morphology (initiation layer, open-top, nanograss, etc.). Next crucial aspects of anodic nanostructuring, tailored for biomedical applications will be shown. Finally, a synthetic overview of biomedical applications using such nanostructures [4-6] and their future prospects will be shown and discussed.
Keywords: Electrochemical anodization, TiO2 nanotubes, Biomedical applications
References
1. K. Lee; A. Mazare; P. Schmuki Chem. Rev. 2014, 114, 9385.
2. J. Park, A. Cimpean, A. B. Tesler, A. Mazare, Nanomaterials 2021, 11, 2359.
3. A. Mazare, ACS Appl. Mater. Interfaces 2022, 14, 13, 14837.
4. R. Ion, M.G. Necula, A. Mazare, V. Mitran, P. Neacsu, P. Schmuki, A. Cimpean, Current Medicinal Chemistry 2020, 20, 1.
5. A. Mazare, J. Park, S. Simons, S. Mohajernia, I. Hwang, J.E. Yoo, H. Schneider, M.J. Fischer, P. Schmuki, Acta Biomaterialia, 2019, 97, 681.
6. M.G. Necula, A. Mazare, A.M. Negrescu, V. Mitran, S. Ozkan, R. Trusca, J. Park, P. Schmuki, A. Cimpean, Int. J. Mol. Sci. 2022, 23, 3558.
Biography: Anca Mazare received her Ph.D. in Chemistry from Politechnica University of Bucharest, Romania, in 2012 under the supervision of Prof. Demetrescu. She joined the group of Prof. P. Schmuki at the University of Erlangen-Nuremberg, Germany, in 2012 as a postdoctoral fellow, and was a visiting associate professor to Tohoku University from September 2021 to February 2022. Her scientific activity comprises synthesis and modification of semiconductor nanomaterials for biomedical and energy-related applications. She has published more than 75 papers in international journals, has an h-index of 27, and numerous oral presentation/invited talks at international conferences.